Protein Details: Protein orai-2

Protein ID

ICDB_Pro_1411

Protein Name

Protein orai-2

Gene Name

ORAI2; C7orf19; CBCIP2; TMEM142B; PP1729

Organism

Homo sapiens (Human)

Length

254 amino acids

AlphaFoldDB

AF-Q96SN7-F1-model_v4.pdb

Function

Ca(2+) release-activated Ca(2+)-like (CRAC-like) channel subunit which mediates Ca(2+) influx and increase in Ca(2+)-selective current by synergy with the Ca(2+) sensor; STIM1.

Sequence

MSAELNVPIDPSAPACPEPGHKGMDYRDWVRRSYLELVTSNHHSVQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLETQYQYPRPLLIAFSACTTVLVAVHLFALLISTCILPNVEAVSNIHNLNSISESPHERMHPYIELAWGFSTVLGILLFLAEVVLLCWIKFLPVDARRQPGPPPGPGSHTGWQAALVSTIIMVPVGLIFVVFTIHFYRSLVRHKTERHNREIEELHKLKVQLDGHERSLQVL

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Anemia;Congenital Dyserythropoietic;Type Iv and Acrofacial Dysostosis;Cincinnati Type

Location

DOI ID

10.1038/ng1285; 10.1038/nature01782; 10.1101/gr.2596504; 10.1073/pnas.0404089101; 10.1074/jbc.m604589200; 10.1038/nature04702; 10.1074/jbc.m611374200; 10.1038/ncb2045

RefSeq

NP_001119812.1; NP_001258747.1; NP_116220.1